The activation of cholinergic system of soil nematode Caenorhabditis elegans by stressful environment
Keywords:
Caenorhabditis elegans, stress, cholinergic system, behaviorAbstract
In experiments with soil nematodes C. elegans it is shown that 2-hours starvation and heat stress (30 minutes at 33°C) cause activation of nematodes' cholinergic system, revealed in the increase of locomotion sensitivity to partial ACh-esterase inhibition by aldicarb. The reason of cholinergic system activation by heat stress is sensitization of nAChRs, revealed in strong increase in behavior sensitivity to nAChRs' agonists levamisole and nicotine. Adaptive value of C. elegans cholinergic system activation by stressful environmental conditions may be determined by its participation in such behaviors as avoidance of high temperature and food search.
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